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Deutsch: English: Histopathology of gastrocnem...(Photo credit: Wikipedia)

Scientists Discover Clues to Muscle Stem Cell Functions.

Study reveals a potential key to new treatment strategies for Muscular Dystrophy

Newswise — May 14, 2012 – Oakland, Calif. – A study conducted by Children’s Hospital & Research Center Oakland scientists identifies how skeletal muscle stem cells respond to muscle injury and may be stimulated to improve muscle repair in Duchenne Muscular Dystrophy, a severe inherited disease of muscle that causes weakness, disability and, ultimately, heart and respiratory failure.

The study, led by Julie D. Saba, MD, PhD, senior scientist at Children’s Hospital Oakland Research Institute (CHORI), shows that a lipid signaling molecule called sphingosine-1-phosphate or “S1P” can trigger an inflammatory response that stimulates the muscle stem cells to proliferate and assist in muscle repair.
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